Salinomycin (sodium salt) is an antibacterial and coccidiostat compound that shows selective toxicity for the CSCs that exist as a subpopulation within HMLER breast cancer cells (IC 50 s = ~24 versus ~90 μM). 1 At 8 μM, salinomycin treatment of 4T1 and MCF-7-Ras breast cancer cell lines results in a ~2-fold and ~3-fold, respective reduction of CSCs relative to controls. 1 Treatment of 5 mg

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71 Salinomycin inhibited File:Salinomycin-structure.png. From Wikimedia Commons, the free media repository. Jump to navigation Jump to search. File; File history; File usage on Commons; However, two salinomycin derivatives (salinomycin n-butyl amide and salinomycin 2,2,2-trifluoroethyl ester) were identified that showed increased anti-trypanosomal activity with 50 % growth inhibition values in the mid nanomolar range and minimum inhibitory concentrations of below 1 μM similar to suramin, a drug used in the treatment of sleeping sickness. Salinomycin sodium salt Chemical Structure. CAS NO. 55721-31-8. Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.

Salinomycin structure

Local inflammation probably Characteristics and Structure Definition. Cell membrane (also known as plasma membrane or plasmalemma) is a biological membrane that separates the contents of the cell from the outside environment. Functions. Barrier that protects the contents of the cell from the extracellular environment; Anchors the cytoskeleton and defines cellular shape 2021-04-01 Over. 95 %. of our undergraduates enter employment or further study shortly after graduating (HESA 2016/17) Over.

2015-02-06 · Although these two kinases are very similar in sequence and structure, they can often have differential effects on the activation of p38 . Our data in human fibroblasts show that the expression and activation of a constitutively active MKK6 attenuate the effect of salinomycin on p38 and myofibroblast formation (Fig. 8).

We do not sell to patients. Salinomycin sodium salt Chemical Structure. CAS No. : 55721-31-8 I. The Crystal and Molecular Structure of Salinomycin p-Iodophenacyl Ester. BY HARUYASU KINASHI, NOBORU OTAKE AND HIROSHI YONEHARA Institute of The ability of salinomycin to kill both CSCs and therapy-resistant cancer cells may structure of salinomycin was determined by X-ray crystallographic analysis, Salinomycin | C42H70O11 | CID 3085092 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, 15 Jan 2021 This curcumin and salinomycin co-delivery system can be an efficient treatment Solid-state and solution structure of the salinomycin–sodium Visit ChemicalBook To find more Salinomycin(53003-10-4) information like chemical properties,Structure,melting point,boiling point,density,molecular formula is to present an overview of their formula, molecular structure, and properties.

2017-04-01 · The X-ray structure of salinomycin-salicylhydroxamic acid conjugate (11b). The antiproliferative activities of salinomycin-hydroxamic acid conjugates were evaluated in HT-29 colorectal cancer, HGC-27 gastric cancer and triple-negative MDA-MB-231 breast cancer cells using MTT assay ( Table 1 ).

The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists. Salinomycin (Procoxacin) Chemical Structure. CAS NO. 53003-10-4. Salinomycin (Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic agent. Salinomycin is a kind of monocarboxylic acid polyether type antibiotics, produced by the fermentation of Streptomyces albus, possesses a specific cyclic structure, and can form a complex compound with the pathogenic microorganisms and the extracellular cations of coccidian, especially K +, Na +, Rb +, to alter the intracellular and extracellular ion concentrations.

Use in agriculture. Salinomycin is used in chicken feed as a coccidiostat.
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The structure of salinomycin, a new member of the polyether ant ibiotics. Kinashi H. Tetrahed. 2016-03-01 For a structural comparison, salinomycin·Na, SY-1·Na, and 18,19-dihydro SY-1·Na were modeled using the X-ray structure of SY-1·Na as the initial geometry.

42 mg elaiophylin/kg salinomycin sodium. 42 mg elaiofylin/kg salinomycinnatrium. hälsa - eur-lex.europa.eu. 42 mg elaiofylin/kg salinomycinnatrium.
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Conclusions: Synthetic structural analogs of salinomycin, previously shown to exhibit Structure-activity relationship within a series of okadaic acid derivatives.

b Uveal melanoma (UM) cells and ARPE-19 cells were treated with a gradient concentrations of salinomycin for 72 h, and the cell viability was measured by MTS assay. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards.

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av B Borgström · 2016 — Salinomycin analogs : Mechanistic probes and structure–activity relationships against cancer stem cells. Borgström, Björn LU (2016). Mark. Abstract: Cancer

55721-31-8. Chemical structure. Chemical Structure.